On May 6, 2022, substantial changes to Cal/OSHA’s COVID-19 Prevention Emergency Temporary Standard (ETS) took effect. The changes, which are in effect until December 31, 2022, govern all California employers not subject to the Aerosol Transmissible Diseases Standard. Important changes include leaving mask guidance to the California Department of Public Health and the removal of all cleaning requirements for workplaces. Some definitions and standards for testing and exclusion were also changed. Some important requirements have remained the same, however. Employers must still have effective COVID-19 Prevention Plans and provide training on COVID-19 prevention to all employees.